In the dynamic landscape of molecular biology, plasmids—small, circular, double-stranded DNA molecules—play a pivotal role. They are the workhorses of genetic engineering, serving as vectors for introducing new genes into cells. To ensure the accuracy of these genetic manipulations, a powerful tool is employed—whole plasmid sequencing. In this post, we’ll explore the importance of whole plasmid sequencing, its potential beneficiaries, and take a brief look at our offerings here at Eurofins Genomics.

The Power of Whole Plasmid Sequencing

Whole plasmid sequencing is a cornerstone in the field of genomics. It allows researchers to confirm the precise genetic modifications made to a plasmid and identify any potential mutations or alterations that may have occurred during the cloning process. This is crucial in ensuring the accuracy and integrity of genetic manipulations, which form the basis of many scientific and medical breakthroughs.

Moreover, whole plasmid sequencing can provide valuable insights into the function of specific genes, the mechanisms of genetic diseases, and the development of new treatments and therapies. It can also be used in the field of synthetic biology to design and construct new biological parts and devices.

Who Stands to Benefit?

Whole plasmid sequencing is an invaluable tool for a wide range of professionals in the field of life sciences. This includes molecular biologists, geneticists, bioengineers, and researchers working in biotechnology companies and academic institutions. It is also beneficial for clinicians and medical researchers involved in the development of gene therapies and personalized medicine.

Convenience of Eurofins Genomics Services

At Eurofins Genomics, we understand that convenience is key for our customers. That’s why we offer a network of dropboxes for easy sample submission, eliminating the need for complex shipping arrangements. Each sample can be tracked using a unique barcode, ensuring traceability and security throughout the process. This user-friendly approach allows researchers to focus on their work, knowing that their samples are in safe and capable hands.

Supporting Our Customers in Data Interpretation

Understanding and interpreting sequencing data can be a complex task. To assist our customers in this process, we at Eurofins Genomics provide comprehensive support in data interpretation. We offer a detailed explanation of the data output, including the meaning of different quality

scores and how to interpret them. We also provide guidelines on how to handle and troubleshoot common issues, such as the presence of ambiguous bases or low-quality regions. This support helps our customers to get the most out of their sequencing results and ensures optimal outcomes for their research projects.

Eurofins Genomics: A Key Player

We at Eurofins Genomics are proud to be a leading provider of whole plasmid sequencing services. We utilize Next Generation Sequencing (NGS) generation 3 technology, which allows for the rapid sequencing of entire plasmids without the need for primer design and synthesis.

Key features of our service include:

  • Fast Turnaround: The typical turnaround time for the sequencing process is one business day from the receipt of samples.
  • High Accuracy: The use of Oxford Nanopore technology ensures a raw read accuracy of 98.3% and a consensus accuracy for Single Nucleotide Polymorphisms (SNPs) of 99.6% with 50X coverage.
  • Simplicity: The elimination of the need for primers or library prep simplifies the process, allowing researchers to focus on the analysis and interpretation of the sequencing results.


In conclusion, whole plasmid sequencing is more than just a tool—it’s a game changer in the field of genomics. Its power lies not only in its ability to provide accurate and comprehensive genetic information, but also in its potential to revolutionize the daily work of researchers. By making the complex simple, whole plasmid sequencing is paving the way for new discoveries and advancements in the life sciences.

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