In 1977, Frederick Sanger and his colleagues Nicklen and Coulson introduced the chain-terminator method or dideoxy sequencing or simply Sanger sequencing as we know it. Similar to the moon landing, Sanger sequencing changed the world of biology and dominate the sequencing world for the next 30 years. Just like Armstrong, Aldrin and Collins stood on the shoulders of giants such as Hans Lippershey and Galileo Galilei who invented the telescope in 1608/1609, or the Russian cosmonaut Yuri Gagarin who was the first human in space (12th April 1961), Sanger and his colleagues also stood on the shoulders of giants:
- Francis Crick, James Watson and Rosalind Franklin, who introduced the world to the double helical structure of DNA in 1953.
- Marshal Nirenberg, who demonstrated that different combinations of DNA bases encode for specific amino acids in 1961.
- Robert Holley and colleagues, who were the first to sequence yeast transfer RNA (tRNA) using RNAses with base specificity in 1965.
- Ray Wu, who was first to decipher a short sequence of DNA by using a technique called primer extension in 1970.
- Walter Fiers, who read the first ever DNA sequence of a whole gene – coding for a MS2 virus coating protein – in 1972.
Image: Principle of Sanger sequencing
Since 1977, the world of genomics experienced many profound changes, most notable with the introduction of next generation sequencing based on the sequencing-by-synthesis method. Nowadays, genomics approaches are used to answer scientific questions in research, pharma and diagnostics, agriculture and food, biotechnology, and medical science.
In the spirit of the first manned moon landing 50 years ago, Eurofins Genomics launches “The DNA Universe”. It represents the sheer endless applications for genomics. For every research question in the field of genomics, Eurofins Genomics has a solution. Whether you need Sanger sequencing, primers and probes, next generation sequencing, synthetic genes, CRISPR, or cell line authentication and testing for Mycoplasma contaminations… The DNA Universe always provides the genomic tools for scientists to be explorers. Reach for the stars – We are glad to assist you!
A factor of crucial importance in the universe is light speed. It is the universe’s measuring unit for velocity. In the universe of genomics, we sets the industry standard for speed with our Express services. We realised that our customers need more speed, so we give you:
What are you waiting for? Start your journey now and contact Eurofins Genomics’ mission control, free of charge, about our comprehensive products and services.
Also, stay tuned for our upcoming product innovations and application packages!